An Overview of Analytical Determination of Diltiazem, Cimetidine, Ranitidine, and Famotidine by UV Spectrophotometry and HPLC Technique

Author:

Shafi Nighat1,Siddiqui Farhan Ahmed1,Naseem Huma2ORCID,Sher Nawab3,Zubair Arif4ORCID,Hussain Azhar5,Sial Ali Akbar1,Baig Mirza Tasawer1ORCID

Affiliation:

1. Faculty of Pharmacy, Federal Urdu University Arts Science and Technology, Karachi 75300, Pakistan

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan

3. Department of Chemistry, University of Karachi, Karachi 75270, Pakistan

4. Department of Environmental Sciences, Faculty of Science, Federal Urdu University Arts Science and Technology, Karachi 75300, Pakistan

5. Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan

Abstract

This review article recapitulates the analytical methods for the quantitative determinations of diltiazem and three H2receptor antagonists (cimetidine, ranitidine, and famotidine) by one of the spectroscopic technique (UV spectrophotometery) and separation technique such as high-performance liquid chromatography (HPLC). The clinical and pharmaceutical analysis of these drugs requires effective analytical procedures for quality control, pharmaceutical dosage formulations, and biological fluids. An extensive survey of the literature published in various analytical and pharmaceutical chemistry-related journals has been compiled in its review. A synopsis of reported spectrophotometric and high-performance liquid chromatographic methods for individual drug is integrated. This appraisal illustrates that majority of the HPLC methods reviewed are based on the quantitative analysis of drugs in biological fluids, and they are appropriate for therapeutic drug monitoring purpose.

Publisher

Hindawi Limited

Subject

General Chemistry

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