The Reliability of Highly Elevated CA 19-9 Levels

Author:

Osswald B. R.1,Klee F. E.2,Wysocki S.2

Affiliation:

1. Salem Medical Center, Dept. of Medicine, Heidelberg, F.R.C., Germany

2. Salem Medical Center, Dept. of Surgery, Heidelberg, F.R.C., Germany

Abstract

CA 19-9 is used as a tumour marker of the upper gastrointestinal tract. However, extremely elevated CA 19-9 levels are found also in patients with benign diseases. Cholestasis was present in 97.1 % of patients with high elevated CA 19-9, independent of their primary disease. 50% of patients with non-malignant diseases and increased CA 19-9 levels showed liver cirrhosis, cholecystitis, pancreatitis and/or hepatitis. In 8.8% no explanation was found for the extremely high CA 19-9 level. The results provide evidence of different factors influencing the CA 19-9 level.

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

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