THE ROLE OF CA 19-9 IN PREDICTING TUMOR RESECTABILITY AND PROGNOSIS IN CARCINOMA HEAD OF THE PANCREAS.

Abstract

Background: Pancreatic cancer is the fth leading cause of cancer death.. Pancreatic cancer is diicult to diagnose in its early stages. at the time presentation nearly 50% cases have distant metastsis. CA 19-9 is tumor associated mucin glycoprotein present in epithelial tissues of pancreas, biliary ductularcells, stomach, gall bladder. Blood levels may be elevated in benign as well as malignant conditions. Aims And Objectives: To study the relation between levels of CA 19-19 and tumor respectability in cases of carcinoma head of pancreas. To study the relation between levels of CA 19-9 and prognosis of the cases. Materials And Methods: A Retrospective analysis of all the cases of carcinoma head of pancreas admiited over a period of 2 years, June 2019 to may 2021 at king George Hospital Visakhapatnam and in them the data was collected from all the patients of ca head of pancrteas on basis of CECT, MRCP. CA 19-9 levels were measured and recorded. During surgery the operative ndings on operability and prognosis were documented and tabulated aganist correspoding CA 19-9 levels. Results: A total of 45 cases Carcinoma head of pancreas of which 30 were operated; of which 21 cases were operable and underwent whipples procedure and 9 under went palliative bypass procedure. CA 19-9 was elevated in all the cases. In operable cases (21) CA 19-9 levels were elevated but not more than 1000IU/ml. Among inoperable cases (24) 85% cases have high levels of CA !9-9 (greater than 1000 IU/ml) Conclusion: Rasie in CA 19-9 levels are seen in many bengin conditions and CA 19-9 is tumor marker for various GI malignancies. Very high levels of CA 19-9 denotes high chances of inooperability and distant metastasis and poor prognosis.