Calreticulin Mutated Essential Thrombocythemia Presenting as Acute Coronary Syndrome

Abstract

Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by a clonal expansion of megakaryocytes. ET can result in both arterial and venous thrombosis. Involvement of the coronary arteries has been reported. Patients who harbor aCALRmutation are half as likely to suffer a thrombotic event as compared to patients with aJAK2mutation. We report a case ofCALR-mutated ET whose initial disease manifestation was a non-ST segment elevation myocardial infarction.