Initiation and Regulation of Complement during Hemolytic Transfusion Reactions-Reference-Cited by-同舟云学术

Initiation and Regulation of Complement during Hemolytic Transfusion Reactions

Published:2012 Issue: Volume:2012 Page:1-12
ISSN:1740-2522
Container-title:Clinical and Developmental Immunology
language:en
Short-container-title:Clinical and Developmental Immunology

Author:

Stowell Sean R.¹,Winkler Anne M.¹,Maier Cheryl L.¹,Arthur C. Maridith²,Smith Nicole H.³^ORCID,Girard-Pierce Kathryn R.¹,Cummings Richard D.²,Zimring James C.⁴,Hendrickson Jeanne E.¹³

Affiliation:

1. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA

2. Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA

3. Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University, Atlanta, GA 30322, USA

4. Puget Sound Blood Center Research Institute, Seattle, WA 98102, USA

Abstract

Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the role of complement in initiating and regulating hemolytic transfusion reactions and will discuss potential strategies aimed at mitigating or favorably modulating complement during incompatible red blood cell transfusions.

Publisher

Hindawi Limited

Subject

General Medicine,Immunology,Immunology and Allergy

Link

http://downloads.hindawi.com/journals/jir/2012/307093.pdf

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