Sulfated Polysaccharides Isolated from ClonedGrateloupia filicinaand Their Anticoagulant Activity-Reference-Cited by-同舟云学术

Sulfated Polysaccharides Isolated from ClonedGrateloupia filicinaand Their Anticoagulant Activity

Published:2015 Issue: Volume:2015 Page:1-5
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Chen Xiaolin¹,Yang Shengfeng²,Wang Jinxia¹,Song Lin¹,Xing Ronge¹,Liu Song¹,Yu Huahua¹,Li Pengcheng¹

Affiliation:

1. Institute of Oceanology, Chinese Academy of Sciences, No. 7 Nanhai Road, Qingdao, Shandong 266071, China

2. Qingdao Tumor Hospital, No. 127 Siliu Nan Road, Qingdao, Shandong 266042, China

Abstract

Sulfated polysaccharides (GSP) were isolated from the clonedGrateloupia filicinawhich was cultured in Jiaozhou Bay, Qingdao, China. The yield of GSP was 15.75%. The total sugar and sulfate were 40.90 and 19.89%, respectively. And the average molecular weight was 11.7 KDa. The results of neutral sugar analysis showed that GSP was mainly sulfated polysaccharides of galactose. The experiments for activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) anticoagulant assays in vitro indicated that GSP was a good potential anticoagulant. Therefore, this study supplied new thought for the clonedGrateloupia filicinaexploitation of high-value products.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2015/612352.pdf

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