Medullary Thyroid Carcinoma: An Update on Imaging

Author:

Kushchayev Sergiy V.12ORCID,Kushchayeva Yevgeniya S.3,Tella Sri Harsha4ORCID,Glushko Tetiana5,Pacak Karel6,Teytelboym Oleg M.5

Affiliation:

1. Moffitt Cancer Center, Department of Radiology, 12902 USF Magnolia Drive, Tampa, FL 33612, USA

2. Johns Hopkins Hospital, Department of Radiology, 601 N Caroline St, Baltimore, MD 21287, USA

3. Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda 10, Center Dr, Bethesda, MD 20892, USA

4. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of South Carolina School of Medicine, 6311 Garners Ferry Rd, Columbia, SC, USA

5. Department of Radiology, Mercy Catholic Medical Center, 1500 Lansdowne Ave, Darby, PA 19023, USA

6. Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD/NIH), 10 Center Dr, Bethesda, MD 20892, USA

Abstract

Medullary thyroid carcinoma (MTC), arising from the parafollicular C cells of the thyroid, accounts for 1–2% of thyroid cancers. MTC is frequently aggressive and metastasizes to cervical and mediastinal lymph nodes, lungs, liver, and bones. Although a number of new imaging modalities for directing the management of oncologic patients evolved over the last two decades, the clinical application of these novel techniques is limited in MTC. In this article, we review the biology and molecular aspects of MTC as an important background for the use of current imaging modalities and approaches for this tumor. We discuss the modern and currently available imaging techniques—advanced magnetic resonance imaging (MRI)-based techniques such as whole-body MRI, dynamic contrast-enhanced (DCE) technique, diffusion-weighted imaging (DWI), positron emission tomography/computed tomography (PET/CT) with 18F-FDOPA and 18F-FDG, and integrated positron emission tomography/magnetic resonance (PET/MR) hybrid imaging—for primary as well as metastatic MTC tumor, including its metastatic spread to lymph nodes and the most common sites of distant metastases: lungs, liver, and bones.

Funder

National Institutes of Health

Publisher

Hindawi Limited

Subject

Endocrinology, Diabetes and Metabolism

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3