Current Understanding and Management of Medullary Thyroid Cancer

Author:

Roy Madhuchhanda1,Chen Herbert1,Sippel Rebecca S.1

Affiliation:

1. Department of Surgery, University of Wisconsin, Madison, Wisconsin, USA

Abstract

Learning Objectives Identify and evaluate a patient with a diagnosis of medullary thyroid cancer. Utilize genetic testing for the RET proto-oncogene and explain how the location of the mutation affects the risks for the patient. Select among the surgical treatment options for patients with medullary thyroid cancer, including prophylactic surgery in genetic carriers.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Reference65 articles.

1. Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the united states during 1996;Hundahl;US and German Thyroid Cancer Study Group An American College of Surgeons Commission on Cancer Patient Care Evaluation study Cancer,2000

2. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis;Eng;JAMA,1996

3. Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC;Mulligan;Nat Genet,1994

4. Multiple endocrine neoplasia type 2: An overview;Moline;Genet Med,2011

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