Helicobacter pyloriInfection and Insulin Resistance in Diabetic and Nondiabetic Population

Abstract

Helicobacter pylori(HP) is a common worldwide infection with known gastrointestinal and nongastrointestinal complications. One of the gastrointestinal side effects posed for this organism is its role in diabetes and increased insulin resistance. The aim of this study was to evaluate the association betweenHPand insulin resistance in type 2 diabetic patients and nondiabetics. This cross-sectional study was carried out from May to December 2013 on 211 diabetic patients referred to diabetes clinic of Shahid Beheshti Hospital of Qom and 218 patients without diabetes.HPwas evaluated using serology method and insulin resistance was calculated using HOMA-IR. The prevalence ofH. pyloriinfection was 55.8% and 44.2% in diabetics and nondiabetics(P=0.001). The study population was divided into twoHPpositive and negative groups. Among nondiabetics, insulin resistance degree was3.01±2.12and2.74±2.18inHP+ andHP− patients, respectivelyP=0.704. Oppositely, insulin resistance was significantly higher in diabeticHP+ patients rather than seronegative ones(4.484±2.781versus3.160±2.327,P=0.013). In diabetic patients, in addition to higher prevalence ofHP, it causes a higher degree of insulin resistance.