Effects of Helicobacter pylori Infection on Insulin Resistance in Type 2 Mellitus Diabetics and Non-Diabetics Subjects at Brazzaville University Hospital

Abstract

Introduction: H.pylori infection is the most common bacterial infection worldwide and is associated with gastrointestinal diseases and extra-gastrointestinal pathologies such as diabetes mellitus and insulin resistance. Objective: To evaluate insulin resistance in diabetics and non-diabetics infected with H. pylori. Methods: We conducted a descriptive cross-sectional study. 90 patients were selected and divided into two groups, 44 patients with T2DM and 46 non-diabetic patients. All information concerning the age and sex of subjects was collected from medical records. Insulin levels were determined by ELISA, blood glucose and HbA1C levels by Cobas c 311, and the HOMA-IR index was calculated. Results: The mean age of T2DM patients was 51 ± 11 years, and that of NDT patients 40±15 years. Women (68) predominated over men (22), with a sex ratio of 0.32. The mean values for T2DM patients were: glycemia 12.6±2.3 mmol/l, HbA1C 10.37±2.9%, HOMA-IR 2.69±1.35 (p<0.001), Insulinemia 8.71±3.14 μU/ml (p= 0.801). Univariate logistic regression analysis showed: Glycemia OR 2.29 [95% IC 1.80-4.5], HbA1C OR 3.08 [95% IC 0.87-1.02], Insulin OR 1.02 [95% IC 1.0-0.16] and HOMA-IR OR 4.4 [95% IC 0.55-0.95]. Means for NDT infections were: blood glucose 9.7±1.0 mmol/l, insulin 9.7±1.64 μU/ml, HOMA-IR 1.45±0.42, HbA1C 8.6±0.9%. Univariate logistic regression analysis showed: Blood glucose OR1.1 [95% IC1.01-2.14], HbA1C OR 1.35 [95% IC 0.08-1.34], Insulin OR 0.51 [95% IC 0.12-1.08], HOMA-IR OR 2.4 [95% IC 0.32-1.45]. Conclusion: Our study showed a statistical significant difference between H.pylori infection and Insulin resistance, also confirms the link of both.Abbreviations: T2DM: Type two diabetes of mellitus, NDT: No-Diabetics, OR: Odd ratio.