Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole-Reference-Cited by-同舟云学术

Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole

Published:2008-07-01 Issue: Volume:2008 Page:1-7
ISSN:0793-0291
Container-title:Metal-Based Drugs
language:en
Short-container-title:Metal-Based Drugs

Author:

Medvetz Doug A.¹,Hindi Khadijah M.¹,Panzner Matthew J.¹,Ditto Andrew J.²,Yun Yang H.²,Youngs Wiley J.¹

Affiliation:

1. Knight Chemical Laboratory 105, Department of Chemistry, The University of Akron, Akron, OH 44325-3601, USA

2. Olsen Research Center 301D, Department of Biomedical Engineering, The University of Akron, Akron, OH 44325-0302, USA

Abstract

A class of Ag(I) N-heterocyclic carbene silver complexes, 1–3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1–3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.

Publisher

Hindawi Limited

Subject

Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology

Link

http://downloads.hindawi.com/archive/2008/384010.pdf

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