Dietary Tenebrio molitor Larvae Meal Inclusion Exerts Tissue-Specific Effects on Cellular, Metabolic, and Antioxidant Status in European Sea Bass (Dicentrarchus labrax) and Gilthead Seabream (Sparus aurata)

Author:

Bousdras Thomas1,Feidantsis Konstantinos1ORCID,Panteli Nikolas1ORCID,Chatzifotis Stavros2ORCID,Piccolo Giovanni3ORCID,Gasco Laura4ORCID,Gai Francesco5ORCID,Antonopoulou Efthimia1ORCID

Affiliation:

1. Laboratory of Animal Physiology, Department of Zoology, School of Biology, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece

2. Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Centre for Marine Research, Gournes Pediados, P.O. Box 2214, GR-71003, Heraklion, Crete, Greece

3. Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Via F. Delpino 1, 80137 Naples, Italy

4. Department of Agricultural, Forest and Food Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco, Italy

5. Institute of Sciences of Food Production, National Research Council, Largo Paolo Braccini 2, 10095 Grugliasco, Italy

Abstract

The present study addresses the effects of dietary Tenebrio molitor (TM) larvae meal inclusion on cytoprotective, cell death pathways, antioxidant defence, and intermediate metabolism in the heart, muscle, and digestive tract of gilthead seabream (Sparus aurata) and European sea bass (Dicentrarchus labrax). Three experimental diets were formulated to contain 0%, 25%, or 50% inclusion TM levels. Heat Shock Proteins (HSPs) induction was apparent in both species’ muscle at 50% inclusion. Conversely, p44/42 Mitogen-Activated Protein Kinase (MAPK) activation was increased ( p < 0.05 ) in both species’ muscle and digestive tract at 25% inclusion. Regarding the apoptotic machinery, TM inclusion exerted no influence on gilthead seabream, while suppression through autophagy may have occurred in the muscle. However, significant apoptosis ( p < 0.05 ) was evident in European sea bass muscle and digestive tract. Both fish species’ heart seemed to additionally rely on lipids compared to muscle and digestive tract. In contrast to gilthead seabream, European sea bass exhibited increased ( p < 0.05 ) antioxidant activity at 50% TM inclusion. The present findings highlight the dietary derived induction of cellular responses in a species- and tissue-specific manner, whereas European sea bass appears to be more susceptible to TM inclusion.

Funder

Hellenic Foundation for Research and Innovation

Publisher

Hindawi Limited

Subject

Aquatic Science

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