Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations-Reference-Cited by-同舟云学术

Simple UV Spectrophotometric Determination of Duloxetine Hydrochloride in Bulk and in Pharmaceutical Formulations

Published:2010 Issue:3 Volume:7 Page:785-788
ISSN:0973-4945
Container-title:E-Journal of Chemistry
language:en
Short-container-title:E-Journal of Chemistry

Author:

Yunoos Mohammad¹,Sankar D. Gowri²,Kumar B. Pragati¹,Hameed Shahul¹,Hussain Azmath¹

Affiliation:

1. Nimra College of Pharmacy, Jupudi, Ibrahimpatnam, Vijayawada, India

2. University College of Pharmaceutical Sciences, Andhra University, Visakhapatanam, Andhra Pradesh, India

Abstract

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of duloxetine hydrochloride in bulk and in pharmaceutical formulations. Duloxetine hydrochloride exhibits absorption maxima at 288 nm with apparent molar absorptivity of 0.97x104L/mol.cm in 0.1 N HCL. Beer's law was found to be obeyed in the concentration range of 5-30 μg/mL. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its capsule dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studies.

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2010/709176.pdf

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