Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-ProducingKlebsiella pneumoniaeInfections: A Report of 3 Cases-Reference-Cited by-同舟云学术

Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-ProducingKlebsiella pneumoniaeInfections: A Report of 3 Cases

Published:2011 Issue: Volume:2011 Page:1-5
ISSN:1687-9627
Container-title:Case Reports in Medicine
language:en
Short-container-title:Case Reports in Medicine

Author:

Gomez Eric¹,Sanchez Martha¹,Gul Zonaira¹,Urban Carl²,Mariano Noriel²,Eng Robert H. K.³,Huang David B.³,Chiang Tom³

Affiliation:

1. Infectious Disease Division, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103-2714, USA

2. Infectious Disease Division, Department of Medicine, New York Hospital Queens, Flushing, NY 11355, USA

3. Infectious Disease Division, Department of Medicine, VA New Jersey Health Care System, 385 Tremont Avenue, 111-ID, East Orange, NJ 07018, USA

Abstract

Management of patients with KPC-harboring Enterobacteriaceae has become a significant and challenging scenario. We report three cases of KPC-producingKlebsiella pneumoniaebacteremia that were successfully treated using combination therapy with polymyxin B and other antimicrobials. Serum bactericidal titers were determined and provided additional clinical guidance in the management of such patients.

Publisher

Hindawi Limited

Subject

General Medicine

Link

http://downloads.hindawi.com/journals/crim/2011/659769.pdf

Reference31 articles.

1. Antimicrobial Synergy Testing Based on Antibiotic Levels, Minimal Bactericidal Concentration, and Serum Bactericidal Activity

2. Detection and treatment options for Klebsiella pneumoniae carbapenemases (KPCs): an emerging cause of multidrug-resistant infection

3. In Vitro Activity of Fosfomycin against bla KPC -Containing Klebsiella pneumoniae Isolates, Including Those Nonsusceptible to Tigecycline and/or Colistin

4. Novel Antibiotic Combinations against Infections with Almost Completely Resistant Pseudomonas aeruginosa and Acinetobacter Species

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