In Vitro Activity of Fosfomycin against bla KPC -Containing Klebsiella pneumoniae Isolates, Including Those Nonsusceptible to Tigecycline and/or Colistin-Reference-Cited by-同舟云学术

In Vitro Activity of Fosfomycin against bla KPC -Containing Klebsiella pneumoniae Isolates, Including Those Nonsusceptible to Tigecycline and/or Colistin

Published:2010-01 Issue:1 Volume:54 Page:526-529
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Endimiani Andrea¹²,Patel Gopi³,Hujer Kristine M.¹²,Swaminathan Mahesh³,Perez Federico¹²,Rice Louis B.²,Jacobs Michael R.⁴,Bonomo Robert A.¹²⁵⁶

Affiliation:

1. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio

2. Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio

3. Department of Medicine, Mount Sinai School of Medicine, New York, New York

4. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio

5. Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio

6. Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio

Abstract

ABSTRACT In vitro activity of fosfomycin was evaluated against 68 bla KPC -possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains. By agar dilution, 93% of the overall KpKPC were susceptible (MIC 50/90 of 16/64 μg/ml, respectively). The subgroup of 23 tigecycline- and/or colistin-nonsusceptible strains showed susceptibility rates of 87% (MIC 50/90 of 32/128 μg/ml, respectively). Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01235-09

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