MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer

Author:

Liu Zhiguang1,Wang Xinlian2,Cao Liqiang3,Yin Xiaowei1ORCID,Zhang Qian1ORCID,Wang Lan3ORCID

Affiliation:

1. Department of Respiratory and Critical Care Medicine, Changzhou Second People’s Hospital Affiliated to Nanjing Medical University, Changzhou 213164, Jiangsu, China

2. Department of Thoracic Surgery, Wuxi Branch of Zhongda Hospital Affiliated to Southeast University, Wuxi 214105, Jiangsu, China

3. Department of Respiratory and Critical Care Medicine, The Jiangyin Clinical College of Xuzhou Medical University, Jiangyin 214400, Jiangsu, China

Abstract

Background. Many researches revealed that microRNAs (miRNAs) function as potential oncogene or tumor suppressor gene. As an antioncogene, miR-877-5p was reduced in many tumors. Objective. This research aimed to explore the biological role and mechanisms of miR-877-5p, which may help patients with non-small-cell lung cancer (NSCLC) find effective therapeutic targets. Methods. The downstream targets of miR-877-5p were predicted by Bioinformatics software. RT-qPCR and western blot were employed to analyze the gene levels. The impacts of miR-877-5p and FOXM1 were assessed by cell function experiments. Results. The miR-877-5p was reduced in NSCLC. In addition to this, it also inhibited cell progression of NSCLC cells in vitro. Moreover, the upregulation of FOXM1 expression restored the inhibitory effect of enhancement of miR-877-5p. Conclusions. Taken together, miR-877-5p inhibited cell progression by directly targeting FOXM1, which may provide potential biomarkers for targeted therapy of NSCLC.

Funder

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy

Publisher

Hindawi Limited

Subject

Pulmonary and Respiratory Medicine

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