In VivoAnti-CandidaActivity of Phenolic Extracts and Compounds: Future Perspectives Focusing on Effective Clinical Interventions

Abstract

Candidaspecies have increasingly deserved a special attention among the medical community. In spite of the presence ofCandidaspecies as a human commensal, alarming rates of local and systemic infections have been observed, varying from moderate to severe impact. Currently available antifungal drugs have progressively lost their effectiveness, pointing urgently the problem of the microorganisms with acquired-resistance. Natural matrices are secularly used for numerous purposes, being inclusive and highly effective as antimicrobials. Increasing evidence gives a particular emphasis to the contribution of phenolic extracts and related individual compounds.In vitrostudies clearly confirm their prominent effects, but the confirmation throughin vivostudies, including the involved mechanisms of action, is not so much deepened. Therefore, the present report aims to provide extensive knowledge about all these aspects, highlighting the most efficient phytochemical formulations, including therapeutic doses. Further studies need to be incited to deepen knowledge on this area, namely, focused on clinical trials to provide safer and more effective antimicrobials than the current ones.