Mathematical Modeling to Study Multistage Stem Cell Transplantation in HIV-1 Patients-Reference-Cited by-同舟云学术

Mathematical Modeling to Study Multistage Stem Cell Transplantation in HIV-1 Patients

Published:2019-08-19 Issue: Volume:2019 Page:1-8
ISSN:1026-0226
Container-title:Discrete Dynamics in Nature and Society
language:en
Short-container-title:Discrete Dynamics in Nature and Society

Author:

Qudah Manar A. Al¹^ORCID,Zarea Sana’a A.¹,Kallel-Jallouli Saoussan A.²

Affiliation:

1. Mathematical Science Department, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia

2. Université de Tunis El Manar, LR03ES04, Faculté des Sciences de Tunis, 2092, Tunis, Tunisia

Abstract

Stem cells as a therapeutic measure for the treatment of different diseases have a great potential to give rise to different mature cells as they could be used to treat HIV-1 patients when provided with the convenient factors. Thus, this paper proposes a new mathematical model, represented by a system of ODEs, to study the effect of stem cell transplantation for HIV-1 patients. Since stem cells lineage passes through many stages to become more specialized cell types, investigating (theorizing) the best stage for these cells to be engrafted was needed. The proposed system of ODEs can help medicine make the right decision about the proposed therapy.

Funder

Princess Nourah Bint Abdulrahman University

Publisher

Hindawi Limited

Subject

Modeling and Simulation

Link

http://downloads.hindawi.com/journals/ddns/2019/6379142.pdf

Reference38 articles.

1. Comparison of HIV-1 and HIV-2 infectivity from a prospective cohort study in Senegal

2. Human immunodeficiency virus type 2

3. Dynamics of HIV infection of CD4+ T cells