Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies-Reference-Cited by-同舟云学术

Interleukin-33 and Inflammatory Bowel Diseases: Lessons from Human Studies

Published:2014 Issue: Volume:2014 Page:1-10
ISSN:0962-9351
Container-title:Mediators of Inflammation
language:en
Short-container-title:Mediators of Inflammation

Author:

Nunes Tiago¹^ORCID,Bernardazzi Claudio²^ORCID,de Souza Heitor S.²³^ORCID

Affiliation:

1. Nutrition and Immunology Chair, Research Center for Nutrition and Food Sciences (ZIEL), Technische Universität München, Gregor-Mendel-Straße 2, 85354 Freising-Weihenstephan, Germany

2. Serviço de Gastroenterologia & Laboratório Multidisciplinar de Pesquisa, Hospital Universitario, Universidade Federal do Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, Ilha do Fundão, 21941-913 Rio de Janeiro, RJ, Brazil

3. D’Or Institute for Research and Education, Rua Diniz Cordeiro 30, Botafogo, 22281-100 Rio de Janeiro, RJ, Brazil

Abstract

Interleukin- (IL-) 33 is a widely expressed cytokine present in different cell types, such as epithelial, mesenchymal, and inflammatory cells, supporting a predominant role in innate immunity. IL-33 can function as a proinflammatory cytokine inducing Th2 type of immune response being involved with the defense against parasitic infections of the gastrointestinal tract. In addition, it has been proposed that IL-33 can act as a signaling molecule alerting the immune system of danger or tissue damage. Recently, in the intestinal mucosa, overexpression of IL-33 has been reported in samples from patients with inflammatory bowel diseases (IBD). This review highlights the available data regarding IL-33 in human IBD and discusses emerging roles for IL-33 as a key modulator of intestinal inflammation.

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

Link

http://downloads.hindawi.com/journals/mi/2014/423957.pdf

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