HIV-1 Tropism Testing and Clinical Management of CCR5 Antagonists: Quebec Review and Recommendations-Reference-Cited by-同舟云学术

HIV-1 Tropism Testing and Clinical Management of CCR5 Antagonists: Quebec Review and Recommendations

Published:2013 Issue:4 Volume:24 Page:202-208
ISSN:1712-9532
Container-title:Canadian Journal of Infectious Diseases and Medical Microbiology
language:en
Short-container-title:Canadian Journal of Infectious Diseases and Medical Microbiology

Author:

Tremblay Cécile¹²,Hardy Isabelle¹³,Lalonde Richard⁴⁵,Trottier Benoit¹⁵⁶,Tsarevsky Irina⁵⁷,Vézina Louis-Philippe⁵⁸,Roger Michel¹³,Wainberg Mark⁹¹⁰,Baril Jean-Guy¹⁵¹¹

Affiliation:

1. Centre hospitalier de l’Université de Montréal, Canada

2. Laboratoire de santé publique du Québec, Canada

3. HIV Genotyping Program, Canada

4. McGill University Health Centre, Canada

5. Advisory Committee on the Clinical Management of Persons Living with HIV, Canada

6. Clinique médicale l’Actuel, Canada

7. Service de lutte contre les infections transmissibles sexuellement et par le sang, ministère de la Santé et des Services sociaux, Canada

8. Programme national de mentorat sur le VIH-sida, Canada

9. McGill AIDS Centre, Canada

10. McGill University, Montreal, Quebec, Canada

11. Clinique médicale du Quartier Latin, Canada

Abstract

HIV-1 tropism assays play a crucial role in determining the response to CCR5 receptor antagonists. Initially, phenotypic tests were used, but limited access to these tests prompted the development of alternative strategies. Recently, genotyping tropism has been validated using a Canadian technology in clinical trials investigating the use of maraviroc in both experienced and treatment-naive patients. The present guidelines review the evidence supporting the use of genotypic assays and provide recommendations regarding tropism testing in daily clinical management.

Publisher

Hindawi Limited

Subject

Infectious Diseases,Microbiology (medical)

Link

http://downloads.hindawi.com/journals/cjidmm/2013/982759.pdf

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