Affiliation:
1. School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Department of Biophysics, Jedności 8, 41-200 Sosnowiec, Poland
Abstract
Free radicals formed by UV irradiation of the two magistral formulas applied on the skin, salicylic acid and urea, were examined by X-band (9.3 GHz) EPR spectroscopy. The influence of the time of UVA (315–400 nm) irradiation on free radical properties and concentrations in the drug samples was determined. The nonirradiated magistral formula did not contain free radicals. Amplitudes (A) and linewidths (ΔBpp) of EPR spectra were analysed. Fast spin-lattice relaxation process existed in the tested drugs. UV irradiation did not change spin-lattice interactions in the tested magistral formula. Concentrations of free radicals formed by UV irradiation in salicylic acid and urea were ~1017–1018 spins/g. The strongest formation of free radicals under UV irradiation was observed for salicylic acid than for urea. Free radical concentration in salicylic acid increased with the increase of UV irradiation time from 15 minutes to 30 minutes, and after its value remained unchanged. The increase of free radical concentration in urea with UV irradiation time was stated. Salicylic acid is characterized with higher photosensitivity than urea. Salicylic acid, urea, and the skin treated by them should not be stored on UV exposure. The usefulness of EPR spectroscopy to optimize storage conditions of recipe drugs was conformed.
Funder
Medical University of Silesia in Katowice
Subject
General Materials Science,Renewable Energy, Sustainability and the Environment,Atomic and Molecular Physics, and Optics,General Chemistry
Cited by
3 articles.
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