A Polymorphism ofORAI1rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis-Reference-Cited by-同舟云学术

A Polymorphism ofORAI1rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis

Published:2014 Issue: Volume:2014 Page:1-5
ISSN:0962-9351
Container-title:Mediators of Inflammation
language:en
Short-container-title:Mediators of Inflammation

Author:

Yen Jeng-Hsien¹,Chang Che-Mai²,Hsu Yu-Wen²,Lee Chih-Hung³⁴,Wu Mei-Shin²,Hwang Daw-Yang⁵,Chen Ben-Kuen⁶,Liao Hsien-Tzung⁷⁸,Wu Man-Tzu Marcie²⁹,Chang Wei-Chiao²⁹¹⁰¹¹

Affiliation:

1. College of Medicine, Kaohsiung Medical University, and Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 83301, Taiwan

2. Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan

3. Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan

4. Chang Gung University College of Medicine, Taoyuan 33302, Taiwan

5. Division of Nephrology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan

6. Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan

7. Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei 11696, Taiwan

8. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11696, Taiwan

9. Department of Pharmacy, Taipei Medical University-Wan Fang Hospital, Taipei 11696, Taiwan

10. Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan

11. Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan

Abstract

Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors.ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whetherORAI1gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) withinORAI1gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism ofORAI1gene is involved in the susceptibility of RA in a Taiwanese population.

Publisher

Hindawi Limited

Subject

Cell Biology,Immunology

Link

http://downloads.hindawi.com/journals/mi/2014/834831.pdf

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