Deep Learning Technology in Pathological Image Analysis of Breast Tissue

Abstract

To explore the application value of the multilevel pyramid convolutional neural network (MPCNN) model based on convolutional neural network (CNN) in breast histopathology image analysis, in this study, based on CNN algorithm and softmax classifier (SMC), a sparse autoencoder (SAE) is introduced to optimize it. The sliding window method is used to identify cells, and the CNN + SMC pathological image cell detection method is established. Furthermore, the local region active contour (LRAC) is introduced to optimize it and the LRAC fine segmentation model driven by local Gaussian distribution is established. On this basis, the sparse automatic encoder is further introduced to optimize it and the MPCNN model is established. The proposed algorithm is evaluated on the pathological image data set. The results showed that the Acc value, F value, and Re value of pathological cell detection of CNN + SMC algorithm were significantly higher than those of the other two algorithms ( $P$  < 0.05). The Dice, OL, Sen, and Spe values of pathological image regional segmentation of CNN algorithm were significantly higher than those of the other two algorithms, and the difference was statistically significant ( $P$  < 0.05). The accuracy, recall, and F-measure of the optimized CNN algorithm for detecting breast histopathological images were 85.25%, 89.27%, and 80.09%, respectively. In the two databases with segmentation standards, the segmentation accuracy of MPCNN is 55%, 73.1%, 78.8%, and 82.1%. In the deep convolution network model, the training time of the MPCNN algorithm is about 80 min. It shows that when the feature dimension is low, the feature map extracted by MPCNN is more effective than the traditional feature extraction method.