Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer

Author:

Ehteshami Bejnordi Babak1,Veta Mitko2,Johannes van Diest Paul3,van Ginneken Bram1,Karssemeijer Nico1,Litjens Geert4,van der Laak Jeroen A. W. M.4,Hermsen Meyke4,Manson Quirine F3,Balkenhol Maschenka4,Geessink Oscar45,Stathonikos Nikolaos3,van Dijk Marcory CRF6,Bult Peter4,Beca Francisco7,Beck Andrew H78,Wang Dayong78,Khosla Aditya89,Gargeya Rishab10,Irshad Humayun7,Zhong Aoxiao11,Dou Qi1112,Li Quanzheng11,Chen Hao12,Lin Huang-Jing12,Heng Pheng-Ann12,Haß Christian13,Bruni Elia13,Wong Quincy14,Halici Ugur1516,Öner Mustafa Ümit15,Cetin-Atalay Rengul17,Berseth Matt18,Khvatkov Vitali19,Vylegzhanin Alexei19,Kraus Oren20,Shaban Muhammad21,Rajpoot Nasir2122,Awan Ruqayya23,Sirinukunwattana Korsuk21,Qaiser Talha21,Tsang Yee-Wah22,Tellez David4,Annuscheit Jonas24,Hufnagl Peter24,Valkonen Mira25,Kartasalo Kimmo2426,Latonen Leena27,Ruusuvuori Pekka2428,Liimatainen Kaisa24,Albarqouni Shadi29,Mungal Bharti29,George Ami29,Demirci Stefanie29,Navab Nassir29,Watanabe Seiryo30,Seno Shigeto30,Takenaka Yoichi30,Matsuda Hideo30,Ahmady Phoulady Hady31,Kovalev Vassili32,Kalinovsky Alexander32,Liauchuk Vitali32,Bueno Gloria33,Fernandez-Carrobles M. Milagro33,Serrano Ismael33,Deniz Oscar33,Racoceanu Daniel3435,Venâncio Rui36,

Affiliation:

1. Diagnostic Image Analysis Group, Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands

2. Medical Image Analysis Group, Eindhoven University of Technology, Eindhoven, the Netherlands

3. Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands

4. Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands

5. Laboratorium Pathologie Oost Nederland, Hengelo, the Netherlands

6. Rijnstate Hospital, Arnhem, the Netherlands

7. BeckLab, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

8. PathAI, Cambridge, Massachusetts

9. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts

10. Harker School, San Jose, California

11. Center for Clinical Data Science, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts

12. Chinese University of Hong Kong, Hong Kong, China

13. ExB Research and Development GmbH, Munich, Germany

14. Munich Business School, Munich, Germany

15. Department of Electrical and Electronics Engineering, Middle East Technical University, Ankara, Turkey

16. Neuroscience and Neurotechnology, Graduate School of Natural and Applied Sciences, Middle East Technical University, Ankara, Turkey

17. Cancer System Biology Laboratory, Graduate School of Informatics, Middle East Technical University, Ankara, Turkey

18. NLP LOGIX, Jacksonville, Florida

19. Smart Imaging Technologies, Houston, Texas

20. Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario, Canada

21. Tissue Image Analytics Lab, Department of Computer Science, University of Warwick, Coventry, United Kingdom

22. Department of Pathology, University Hospitals Coventry and Warwickshire National Health Service Foundation Trust, Coventry, United Kingdom

23. Department of Computer Science and Engineering, Qatar University, Doha, Qatar

24. Hochschule für Technik und Wirtschaft, Berlin, Germany

25. BioMediTech Institute and Faculty of Medicine and Life Sciences, Tampere University of Technology, Tampere, Finland

26. BioMediTech Institute and Faculty of Biomedical Science and Engineering, Tampere University of Technology, Tampere, Finland

27. Prostate Cancer Research Center, Faculty of Medicine and Life Sciences and BioMediTech, University of Tampere, Tampere, Finland

28. Faculty of Computing and Electrical Engineering, Tampere University of Technology, Pori, Finland

29. Technical University of Munich, Munich, Germany

30. Department of Bioinformatic Engineering, Osaka University

31. University of South Florida, Tampa, Florida

32. Biomedical Image Analysis Department, United Institute of Informatics Problems, Belarus National Academy of Sciences, Minsk, Belarus

33. Visilab, University of Castilla-La Mancha, Ciudad Real, Spain

34. INSERM, Laboratoire d’Imagerie Biomédicale, Sorbonne Universiteś, Pierre and Marie Curie University, Paris, France

35. Pontifical Catholic University of Peru, San Miguel, Lima, Peru

36. Sorbonne University, Pierre and Marie Curie University, Paris, France

Publisher

American Medical Association (AMA)

Subject

General Medicine

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