Antioxidant and Antimycotic Activities of Two NativeLavandulaSpecies from Portugal

Abstract

The antioxidant and antimycotic activities of the essential oils and extracts of two native PortugueseLavandulaspecies,L. stoechassubsp.luisieriandL. pedunculata, were evaluated byin vitroassays. The total phenolics and flavonoids content were also determined. The antioxidant potential was assessed through DPPH radical scavenging, inhibition of lipid peroxidation (ILP), and DNA protection assays. All samples displayed a high DPPH scavenging activity, some of them showing concentration dependence. The majority of the samples were also able to inhibit lipid peroxidation. A strong correlation was observed between the results of DPPH and ILP assays and the flavonoids content of the samples. In the DNA protection assay, all the extracts were able to preserve DNA integrity. The antimycotic activity was performed against twelve fungi belonging to Basidiomycota and Ascomycota Divisions.L. stoechassubsp.luisieriexhibited the broadest activity spectra.L. pedunculataextracts were active against five fungi.Cryptococcus neoformanswas the most sensitive, being inhibited by all the extracts. Our results led to the conclusion thatL. stoechassubsp.luisieriandL. pedunculatacan be useful as new sources of natural antioxidants and antimycotic agents, providing a possible valorization of the existing biodiversity and resources of Portuguese flora.