Affiliation:
1. Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, Toulouse Cedex 4 F-31077, France
Abstract
In order to better define the mechanism and the products of guanine oxidation within DNA, we investigated
the details of the mechanism of guanine oxidation by a metalloporphyrin, Mn-TMPyP, associated to
KHSO5
on oligonucleotides. We found that the three major products of guanine oxidation are formed by
independent reaction routes. The oxidized guanidinohydantoin (1) and the proposed spiro compound 3 derivatives are not precursors of imidazolone lesion (Iz). These guanine lesions as well as their degradation products, may account for non-detected guanine oxidation products on oxidatively damaged DNA.
Subject
Inorganic Chemistry,Drug Discovery,Pharmacology,Toxicology
Cited by
21 articles.
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