High-Density Lipoprotein Cholesterol in Young Nondiabetic Coronary Heart Disease Patients

Author:

Hu Ziyang1ORCID,Cui Jingle2ORCID,Li Xueshan1,Zhou Yaohui3,Cai Lu4,Zhang Shibin5

Affiliation:

1. Department of Cardiology, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan 528400, China

2. Department of Cardiothoracic Surgery, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan 528400, China

3. Emergency Department, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan 528400, China

4. Department of Clinical Laboratory, Zhongshan Hospital of Traditional Chinese Medicine, Zhongshan 528400, China

5. Graduate School of Hunan University of Chinese Medicine, Changsha 410208, China

Abstract

Objective. To investigate the association between the lipid profiles and coronary heart disease (CHD) in nondiabetic patients younger than 65 years of age. Method. 424 patients were enrolled in this study from January 2019 to December 2020. All the patients were screened for clinically indicated coronary angiography. They were divided into two groups according to the coronary angiography results: 340 patients with the presence of CHD (at least one coronary artery stenosis ≥50%) were classified as the CHD group, and the rest with the absence of CHD comprised the normal group. The demographic data and lipid profiles were compared. Result. CHD was higher in males than females (84.5% vs. 62.2%, P < 0.001 ). In the CHD group, the level of high‐density lipoprotein cholesterol (HDL-C) was lower P < 0.001 , while the triglyceride (TG)/HDL-C ratio was higher P = 0.022 . No significant differences were shown between the two groups in terms of age, family history of CHD, hypertension, and the levels of TC, TG, and LDL-C. Gender differences were further explored. In men, except for the level of HDL-C which was significantly lower in the CHD group than that in the normal group P = 0.017 , parameters were comparable. A binary logistic regression model further indicated that HDL-C was associated with CHD (OR = 0.137, 95%CI: 0.031–0.594, P = 0.008 ). Also, with the increase of the number of coronary artery with lesions, the levels of HDL-C decreased significantly in men. In women, no differences were observed between the CHD group and normal group. Conclusion. HDL-C may be inversely associated with the risk of CHD in young nondiabetes patients, especially in men. More research is needed to confirm it.

Funder

Zhongshan Science and Technology Programme Project

Publisher

Hindawi Limited

Subject

Cardiology and Cardiovascular Medicine

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3