Photostability and Photostabilization of Drugs and Drug Products

Author:

Ahmad Iqbal1ORCID,Ahmed Sofia1ORCID,Anwar Zubair1,Sheraz Muhammad Ali1ORCID,Sikorski Marek2

Affiliation:

1. Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Toll Plaza, Super Highway, Gadap Road, Karachi 74600, Pakistan

2. Faculty of Chemistry, Adam Mickiewicz University in Poznan, Umultowska 89b, 61–64 Poznan, Poland

Abstract

Photostability studies of drugs and drug products are an integral part of the product development process in the pharmaceutical industry. These studies are carried out to ensure quality, efficacy, and safety of the formulated products during manufacture, storage, and use. This review deals with the concept of photostability and related aspects and the literature available in the field. It highlights the role of the photochemistry in the photostability studies, describes the functional groups important for the photoreactivity of drugs, explains photophysical processes, and deals with the kinetics of photochemical reactions. The various modes of photodegradation of drugs with examples of selected compounds are presented. The biological consequences of the effect of light on the drug degradation are described. The photostability testing of drugs and drug products and the requirements under ICH guideline are discussed. Some information on the packaging requirements for the formulated products is provided. The various methods used for the photostabilization of solid and liquid dosage forms are also discussed.

Funder

Baqai Institute of Pharmaceutical Sciences

Publisher

Hindawi Limited

Subject

General Materials Science,Renewable Energy, Sustainability and the Environment,Atomic and Molecular Physics, and Optics,General Chemistry

Reference196 articles.

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