Study the Stability of Pharmaceutical eye drop composed of Chloramphenicol and Dexamethasone Sodium Phosphate stored in non-recommended ‎conditions

Author:

Nouman Micheal1

Affiliation:

1. Ph.D. in Drug Control and Bio Pharmacy, Department of Pharmaceutical Technology, Faculty of Pharmacy, Al-Wataniya Private University, Syria.

Abstract

The pharmaceutical formulation stability of drug during its entire shelf life is an important matter and it is affected by many factors, one of the most important of these factors is the environmental conditions encountered during transport, storage and use. As know, the electricity access in developing countries might be a problem and the outage power may impact the stability of refrigerated pharmaceutical products. Aims: The aim of this study is to measured chemical and physical stability of dexamethasone sodium phosphate and chloramphenicol eye drops, commercially marketed as Dexachlor, stored at room temperature while the recommended condition storage is between (2-8C°). Results: After70 days of analyzing the samples, stability study revealed that storing Dexachlor‎eye drops ‎at 25°C does not produce any statistical difference regarding drug content, pH and clarity compared to refrigerated samples. Conclusion: Storing dexamethasone sodium phosphate and chloramphenicol eye drops at room temperature for up to 70 days appears to have no effect on the stability of this pharmaceutical product.

Publisher

A and V Publications

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