The Expressions and Mechanisms of Sarcomeric Proteins in Cancers-Reference-Cited by-同舟云学术

The Expressions and Mechanisms of Sarcomeric Proteins in Cancers

Published:2020-06-30 Issue: Volume:2020 Page:1-16
ISSN:0278-0240
Container-title:Disease Markers
language:en
Short-container-title:Disease Markers

Author:

Yang Xiaojing¹,Ren Hanru²,Guo Xiaomao³⁴,Hu Chaosu³⁵,Fu Jie¹^ORCID

Affiliation:

1. Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600, Yishan Road, Shanghai 200233, China

2. Department of Orthopedics, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai 201300, China

3. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China

4. Shanghai Medical College, Fudan University, Shanghai, China

5. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

Abstract

The sarcomeric proteins control the movement of cells in diverse species, whereas the deregulation can induce tumours in model organisms and occurs in human carcinomas. Sarcomeric proteins are recognized as oncogene and related to tumor cell metastasis. Recent insights into their expressions and functions have led to new cancer therapeutic opportunities. In this review, we appraise the evidence for the sarcomeric proteins as cancer genes and discuss cancer-relevant biological functions, potential mechanisms by which sarcomeric proteins activity is altered in cancer.

Funder

Shanghai Municipal Health Commission

Publisher

Hindawi Limited

Subject

Biochemistry, medical,Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/dm/2020/8885286.pdf

Reference166 articles.

1. Titin Gene and Protein Functions in Passive and Active Muscle

2. Cardiac Disorders and Pathophysiology of Sarcomeric Proteins

3. Epithelial-Mesenchymal Transitions in Development and Disease