Antithrombotic Effects of Five Organic Extracts of Bangladeshi PlantsIn Vitroand Mechanisms inIn SilicoModels-Reference-Cited by-同舟云学术

Antithrombotic Effects of Five Organic Extracts of Bangladeshi PlantsIn Vitroand Mechanisms inIn SilicoModels

Published:2015 Issue: Volume:2015 Page:1-8
ISSN:1741-427X
Container-title:Evidence-Based Complementary and Alternative Medicine
language:en
Short-container-title:Evidence-Based Complementary and Alternative Medicine

Author:

Mahmud Sakib¹,Akhter Samina¹,Rahman Md. Atiar¹,Aklima Jannatul¹,Akhter Shaheen²,Merry Syeeda Rayhana²,Jubair S. M. Rakibul²,Dash Raju³,Emran Talha Bin³

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh

2. Bangladesh Forest Research Institute, Chittagong 4000, Bangladesh

3. Department of Pharmacy, BGC Trust University, Chittagong 4000, Bangladesh

Abstract

This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer aided models were adopted in this study to find out a structure-function correlation between the phytochemical constituents and thrombolytic effects using the secondary metabolites as ligands and tissue plasminogen activator (t-PA) as receptor for the best fit ligand-receptor interaction.

Funder

Bangladesh Agriculture Research Council

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

Link

http://downloads.hindawi.com/journals/ecam/2015/782742.pdf

Reference43 articles.

1. Sustained reflow in dogs with coronary thrombosis with K2P, a novel mutant of tissue-plasminogen activator

2. Terminalia arjuna Wight & Arn.—A useful drug for cardiovascular disorders

3. Coronary Thrombolysis: Streptokinase or Recombinant Tissue-Type Plasminogen Activator?