Free Radicals Scavenging Capacity, Antidiabetic and Antihypertensive Activities of Flavonoid-Rich Fractions from Leaves ofTrichilia emeticaandOpilia amentaceain an Animal Model of Type 2 Diabetes Mellitus

Author:

Konaté Kiessoun12,Yomalan Kassi3,Sytar Oksana4,Zerbo Patrice5,Brestic Marian6ORCID,Patrick Van Damme7,Gagniuc Paul8,Barro Nicolas9

Affiliation:

1. Unit of Formation in Sciences Applied and Technological (UFR/SAT) and Institute of Sciences of the Environment and the Rural Development (ISEDR), Polytechnic University of Dédougou, Burkina Faso

2. Laboratory of Biochemistry and Applied Chemistry, University of Ouagadougou, 09 P.O. Box 848, Ouagadougou 09, Burkina Faso

3. Laboratory of Animal Physiology, UFR Bioscience, University of Felix Houphouet Boigny of Abidjan, 22 P.O. Box 582, Abidjan 22, Cote D’Ivoire

4. Department of Plant Physiology and Ecology, Taras Shevchenko National University of Kyiv, Volodymyrs’ka Street 64, Kyiv 01601, Ukraine

5. Laboratory of Plant Ecology and Biology, University of Ouagadougou, 09 P.O. Box 848, Ouagadougou 09, Burkina Faso

6. Department of Plant Physiology, Slovak Agriculture University in Nitra, A. Hlinku 2, 94976 Nitra, Slovakia

7. Laboratory of Tropical and Subtropical Agronomy and Ethnobotany, Department of Plants Production, Faculty of Biosciences Ingineering, Gent University, Belgium

8. Institute of Genetics, University of Bucharest, 060101 Bucharest, Romania

9. Laboratory of Biochemistry and Molecular Genetics Microbial, University of Ouagadougou, 03 P.O. Box 7131, Ouagadougou 03, Burkina Faso

Abstract

Trichilia emeticaandOpilia amentaceatraditional Burkinabe medicinal plants were investigated to determine their therapeutic potential to inhibit key enzymes in carbohydrate metabolism, which has relevance to the management of type 2 diabetes.In vitroandin vivoantioxidant and antihypertensive potential and antilipidemia and antihyperglycemia activities in an animal model of type 2 diabetes mellitus have been studied. The antioxidant activity of the flavonoids from leaves ofTrichilia emeticaandOpilia amentaceahas been evaluated usingβ-carotene-linoleic acid system, 1,1-diphenyl-2-picrylhydrazyl inhibitory activity, chelation of iron (II) ions, and lipid peroxidation which showed more pronounced antioxidant capacities ofTrichilia emetica. Total cholesterol concentrations decreased in an animal model of type 2 diabetes mellitus under effects of flavonoid-rich fractions from leaves ofTrichilia emeticaandOpilia amentaceahas been observed. Extract of flavonoid-rich fractions fromTrichilia emeticashown maximum radical scavenging activity and possessed marked antiamylase activity which may be due to the presence of certain secondary metabolites. Suggested better antihyperglycemia, antilipidemia, and antihypertensive properties of flavonoid-rich fractions fromTrichilia emeticacompared to the extract ofOpilia amentaceaare demonstrating antidiabetic potential ofTrichilia emeticaas therapeutic targets for the management of type 2 diabetes.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

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