Affiliation:
1. Institute of Chemistry, University of Punjab, Lahore 54590, Pakistan
2. Department of Chemistry, Minhaj University, Lahore, Pakistan
Abstract
Novel sulfonamides were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS,1HNMR, and13CNMR). In vitro, developed compounds were screened for their antibacterial activities against medically important gram (+) and gram (−) bacterial strains, namely,S. aureus,B. subtilis,E. coli, andK. pneumoniae. The antibacterial activities have been determined by measuring MIC values (μg/mL) and zone of inhibitions (mm). Among the tested compounds, it was found that compounds 5a and 9a have most potent activity againstE. coliwith zone of inhibition:31±0.12 mm (MIC: 7.81 μg/mL) and30±0.12 mm (MIC: 7.81 μg/mL), respectively, nearly as active as ciprofloxacin (zone of inhibition:32±0.12 mm). In contrast, all the compounds were totally inactive against the gram (+)B. subtilis.
Subject
General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Cited by
20 articles.
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