Effect of Benzothiazoline Ligand and Corresponding Organoantimony(V) Derivative on the Reproductive System of Male Rats

Abstract

BenzothiazolineHNC6H4SC︹(C6H5)CH:C(OH)COOCH3 1prepared by the condensation reaction of aroyl pyruvate and 2-aminothiophenol has been treated withPh3Sb(OPri)2to yieldPh3Sb[SC6H4NC(C6H5)CH:CO︹COOCH3] 2. These compounds have been characterized by elemental analyses and molecular weight determinations. The probable structures of the ligand as well as antimony complex have been tentatively proposed on the basis of IR and NMR (H1andC13) spectral evidences. Both compounds have been tested for their antifertility activity in male albino rats. The oral administration of compounds1and2at the dose level of 10 mg/rat/day significantly reduced the weights of testes, epididymides, ventral prostate, and seminal vesicles. The production of preleptotene spermatocytes was decreased by36.57%;57.23%, pachytene spermatocytes by40.06%;62.01%, and secondary spermatocytes by52.45%;63.22%, following the treatment of compounds1and2, respectively. The marked reduction in sperm motility and density resulted in infertility by100%. Significant (P<.01) alterations were found in biochemical parameters of reproductive organs in treated animals as compared to control group. It is concluded that all these effects may finally impair the fertility of male rats.