Affiliation:
1. Department of Chemistry, Swargiya P.N.K.S. Government P.G. College, Dausa-303303, India
2. Department of Zoology, Swargiya P.N.K.S. Government P.G. College, Dausa-303303, India
Abstract
Diphenyl antimony(III) and triphenylantimony(V) derivatives of Schiff bases having general formulae Ph2Sb[OC(R)CHC(R′)NC6H5] and Ph3Sb[OC(R)CHC(R′)NC6H5]2 (where R=R′=CH3,C6H5; R = CH3, R′=C6H5), respectively have been prepared. Trivalent organoantimony derivatives have been synthesized by the reaction of RC(O)CHC(R′)-NH(C6H5) with Ph3Sb in 1: 1 molar ratio whereas, pentavalent organoantimony derivatives have been synthesized by the reaction of Ph3SbBr2 with Na[OC(R)CHC(R′)N(C6H5)] in 1:2 molar ratio, respectively in benzene solution. The structures of these complexes have been assigned on the basis of chemical analysis, molecular weight measurements and spectral (IR 1H & 13C NMR) studies. Schiff base (R = CH3, R′ = C6H5 ) and its corresponding organoantimony(III) and antimony(V) compounds were used for evaluation of reproductive physiological activity in male rats and for studying antifertility activity. Compounds were administrated orally for 30 days to male albino rats and after termination of treatment, animal tissue and serum were taken for histopathological, biochemical and hematological parameters
Publisher
Asian Journal of Chemistry
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