HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review-Reference-Cited by-同舟云学术

HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review

Published:2014 Issue: Volume:2014 Page:1-8
ISSN:2314-8861
Container-title:Journal of Immunology Research
language:en
Short-container-title:Journal of Immunology Research

Author:

Cheng Chi-Yuan¹,Su Shih-Chi²^ORCID,Chen Chi-Hua¹,Chen Wei-Li¹,Deng Shin-Tarng¹,Chung Wen-Hung²³⁴

Affiliation:

1. Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 33305, Taiwan

2. Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Linkou 33305, Taiwan

3. College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan

4. Department of Dermatology, Keelung Chang Gung Memorial Hospital, No. 222 Maijin Road, Anle District, Keelung City 20448, Taiwan

Abstract

T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity. This review summarizes the literature on recent progresses in pharmacogenetic studies and clinical application of pharmacogenetic screening based on associations between SCARs and specific HLA alleles to avoid serious conditions associated with drug hypersensitivity.

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

Link

http://downloads.hindawi.com/journals/jir/2014/565320.pdf

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