Affiliation:
1. Department of Chemistry, College of Natural and Computational Sciences, Mekelle University, Mekelle, Ethiopia
Abstract
Indole motifs are one of the most significant scaffolds in the discovery of new drugs. We have described a synthesis of new N-substituted indole derivatives (1-3), and their in vitro antimicrobial activities were investigated. The synthesis of titled compounds has been demonstrated by utilizing commercially available starting materials. The antibacterial and antifungal activities were performed using new strains of bacteria Staphylococcus aureus, Escherichia coli, and Candida albicans using the disc diffusion method. Notably, the compound 4-(1-(2-(1H-indol-1-yl) ethoxy) pentyl)-N,N-dimethyl aniline (1) was found to be most potent than the other analogues (2 and 3), which has shown higher inhibition than the standard drug chloramphenicol.
Cited by
12 articles.
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1. Synthesis, in vitro Α-Glucosidase, and acetylcholinesterase inhibitory activities of novel Indol-Fused Pyrano[2,3-D]Pyrimidine compounds;Bioorganic & Medicinal Chemistry Letters;2024-01
2. Design, Synthesis and Anti-Bacterial Activity Evaluation of Indole-Based Benzophenone and Their Derivatives;Journal of the Turkish Chemical Society Section A: Chemistry;2023-08-30
3. Splicing Indoles and 4,5-Dihydro-1H-pyrazoline Structure Gave Birth to Novel Antiviral Agents: Design, Synthesis, and Mechanism Study;Journal of Agricultural and Food Chemistry;2023-05-09
4. Synthesis, Characterization and ADME Prediction Study of Heterocyclic
Moieties-linked Indole Derivatives as Potential Antimicrobial Agents;Letters in Drug Design & Discovery;2023-01
5. Novel series of N-acyl substituted indole based piperazine, thiazole and tetrazoles as potential antibacterial, antifungal, antioxidant and cytotoxic agents, and their docking investigation as potential Mcl-1 inhibitors;Journal of Molecular Structure;2023-01