PEEP Role in ICU and Operating Room: From Pathophysiology to Clinical Practice

Author:

Vargas M.1,Sutherasan Y.2,Gregoretti C.3,Pelosi P.4

Affiliation:

1. Department of Neurosciences and Reproductive and Odontostomatological Sciences, University of Naples “Federico II,” 80100 Naples, Italy

2. Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

3. Department of Critical Care Medicine, “Città della Salute e della Scienza” Hospital, 10121 Turin, Italy

4. Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, 16132 Genoa, Italy

Abstract

Positive end expiratory pressure (PEEP) may prevent cyclic opening and collapsing alveoli in acute respiratory distress syndrome (ARDS) patients, but it may play a role also in general anesthesia. This review is organized in two sections. The first one reports the pathophysiological effect of PEEP on thoracic pressure and hemodynamic and cerebral perfusion pressure. The second section summarizes the knowledge and evidence of the use of PEEP in general anesthesia and intensive care. More specifically, for intensive care this review refers to ARDS and traumatic brain injured patients.

Publisher

Hindawi Limited

Subject

General Environmental Science,General Biochemistry, Genetics and Molecular Biology,General Medicine

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