Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature-Reference-Cited by-同舟云学术

Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature

Published:2019-09-08 Issue: Volume:2019 Page:1-4
ISSN:2090-6560
Container-title:Case Reports in Hematology
language:en
Short-container-title:Case Reports in Hematology

Author:

Eason Ashley C.¹,Bunting Silvia T.²,Peterson Jess F.³^ORCID,Saxe Debra⁴,Sabnis Himalee S.¹^ORCID

Affiliation:

1. Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta and Emory University, Atlanta, GA, USA

2. Department of Pathology, Children’s Healthcare of Atlanta, Atlanta, GA, USA

3. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

4. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA

Abstract

Acute myeloid leukemia (AML) patients with t(8;16)(p11.2;p13) constitute a small subgroup with a distinct genetic and clinical profile. We present a unique case of a female infant with monocytic AML associated with t(8;19)(p11.2;q13.3), a rarely reported variation of t(8;16)(p11.2;p13). The patient presented with leukemia cutis and demonstrated erythrophagocytosis in the diagnostic bone marrow. She responded well to standard AML chemotherapy and is currently in remission. Here, we highlight her case as the youngest AML patient with t(8;19) described in the literature, discuss the significance and prognostic implications of this genetic variant, and review 8p11.2 fusion proteins in AML.

Publisher

Hindawi Limited

Subject

Cell Biology,Developmental Biology,Embryology,Anatomy

Link

http://downloads.hindawi.com/journals/crihem/2019/4198415.pdf

Reference15 articles.

1. Classification and risk assessment in AML: integrating cytogenetics and molecular profiling

2. Genomics of Acute Myeloid Leukemia Diagnosis and Pathways

3. Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Münster AML-study group

4. AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features

5. Gene Expression Profiling of Acute Myeloid Leukemia with Translocation t(8;16)(p11;p13) and MYST3-CREBBP Rearrangement Reveals a Distinctive Signature with a Specific Pattern of HOX Gene Expression

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