Pediatric acute myeloid leukemia with t(8;16)(p11;p13), a distinct clinical and biological entity: a collaborative study by the International-Berlin-Frankfurt-Münster AML-study group

Author:

Coenen Eva A.1,Zwaan C. Michel12,Reinhardt Dirk3,Harrison Christine J.4,Haas Oskar A.5,de Haas Valerie2,Mihál Vladimir6,De Moerloose Barbara7,Jeison Marta8,Rubnitz Jeffrey E.9,Tomizawa Daisuke10,Johnston Donna1112,Alonzo Todd A.1113,Hasle Henrik14,Auvrignon Anne15,Dworzak Michael5,Pession Andrea16,van der Velden Vincent H. J.17,Swansbury John18,Wong Kit-fai19,Terui Kiminori20,Savasan Sureyya21,Winstanley Mark22,Vaitkeviciene Goda23,Zimmermann Martin3,Pieters Rob1,van den Heuvel-Eibrink Marry M.12

Affiliation:

1. Department of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children’s Hospital, Rotterdam, The Netherlands;

2. Dutch Childhood Oncology Group, the Hague, The Netherlands;

3. Acute Myeloid Leukemia-Berlin-Frankfurt-Münster Study Group, Pediatric Hematology/Oncology, Medical School Hannover, Hannover, Germany;

4. Northern Institute of Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom;

5. St. Anna Children's Hospital and Children’s Cancer Research Institute, Department of Pediatrics, Medical University of Vienna, Vienna, Austria;

6. Czech Pediatric Hematology/Oncology, Department of Pediatrics, University Hospital, Palacky´s University, Olomouc, Czech Republic;

7. Belgian Society of Paediatric Haematology Oncology, Ghent University Hospital, Department of Pediatric Hematology/Oncology, Ghent, Belgium;

8. Cancer Cytogenetic Laboratory, Pediatric Hematology Oncology Department, Schneider Children's Medical Center of Israel, Petach Tikvah, Israel;

9. St. Jude Children’s Research Hospital, Memphis, TN;

10. Japanese Pediatric Leukemia/Lymphoma Study Group, Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan;

11. Children’s Oncology Group, Arcadia, CA;

12. Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada;

13. Department of Preventive Medicine, University of Southern California, Los Angeles, CA;

14. Nordic Society for Pediatric Hematology and Oncology, Department of Pediatrics, Aarhus University Hospital Skejby, Aarhus, Denmark;

15. French Leucémie Aique Myeloide Enfant, Hopital Trousseau, Paris, France;

16. Italian Association of Pediatric Hematology Oncology, Clinica Pediatrica, Università Padova, Padova, Italy;

17. Department of Immunology, Erasmus MC, Rotterdam, The Netherlands;

18. Department of Clinical Cytogenetics, The Royal Marsden Hospital and The Institute of Cancer Research, Sutton, United Kingdom;

19. Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China;

20. Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan;

21. Division of Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI;

22. Department of Pediatric Oncology, Starship Children’s Hospital, Auckland, New Zealand; and

23. Clinic for Children’s Diseases, Centre for Oncology/Haematology, Vilnius University, Vilnius, Lithuania

Abstract

Key Points Pediatric t(8;16)(p11;p13) AML is a rare entity defined by a unique gene expression signature and distinct clinical features. Spontaneous remissions occur in a subset of neonatal t(8;16)(p11;p13) AML cases.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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