MMP2andMMP10Polymorphisms Are Related to Steroid-Induced Osteonecrosis of the Femoral Head among Chinese Han Population

Abstract

Background. Steroid-induced osteonecrosis of the femoral head is a relatively serious condition which seriously reduces patient quality of life. However, the pathogenesis of steroid-induced ONFH is still unclear. In recent years, more scholars have found that the pathogenesis of steroid-induced ONFH is related to susceptibility factors such asMMPs/TIMPssystem. The main purpose of this study is to investigate the correlation betweenMMP2andMMP10gene polymorphisms and steroid-induced ONFH in Chinese Han population.Methods. Six SNPs inMMP2and two SNPs inMMP10were genotyped using Agena MassARRAY RS1000 system from 286 patients of steroid-induced ONFH and in 309 healthy controls. The association betweenMMP2andMMP10polymorphisms and steroid-induced ONFH risk were estimated by the Chi-squared test, genetic model analysis, haplotype analysis, and stratification analysis. The relative risk was estimated by odd ratios (ORs) and 95% confidence intervals (CIs).Result. We found that the minor TG allele of rs470154 inMMP10was associated with an increased risk of steroid-induced ONFH (OR = 1.45, 95% CI, 1.03 – 2.05,p= 0.032). In the genetic model analysis, we found that rs2241146 inMMP2gene and rs470154 inMMP10gene showed a statistically significant association with increased risk of steroid-induced ONFH. The six SNPs (rs470154, rs243866, rs243864, rs865094, rs11646643, and rs2241146) showed a statistically significant association with different clinical phenotypes.Conclusion. Our results verify that genetic polymorphisms ofMMP2andMMP10contribute to steroid-induced ONFH susceptibility in the population of Chinese Han population, and our study provides new insights into the role thatMMP2andMMP10plays in the mechanism of ONFH.