Affiliation:
1. The First Clinical College of Medicine, Lanzhou University, Lanzhou 730000, China
2. Department of Orthopedics, The First Hospital of Lanzhou University, Lanzhou 730000, China
Abstract
Osteonecrosis of the femoral head (ONFH) is a refractory orthopedic condition characterized by bone cell ischemia, necrosis, bone trabecular fracture, and clinical symptoms such as pain, femoral head collapse, and joint dysfunction that can lead to disability. The disability rate of ONFH is very high, which imposes a significant economic burden on both families and society. Steroid-associated osteonecrosis of the femoral head (SANFH) is the most common type of ONFH. However, the pathogenesis of SANFH remains unclear, and it is an urgent challenge for orthopedic surgeons to explore it. In this paper, the pathogenesis of SANFH and its related signaling pathways were briefly reviewed to enhance comprehension of the pathogenesis and prevention of SANFH.
Funder
National Natural Science Foundation of China
Lanzhou University Undergraduate Education and Teaching Level Improvement Cultivation Project
Lanzhou Talent Innovation and Entrepreneurship Project