The Isolation of a NewS-Methyl Benzothioate Compound from a Marine-DerivedStreptomycessp.-Reference-Cited by-同舟云学术

The Isolation of a NewS-Methyl Benzothioate Compound from a Marine-DerivedStreptomycessp.

Published:2012 Issue: Volume:2012 Page:1-4
ISSN:1110-7243
Container-title:Journal of Biomedicine and Biotechnology
language:en
Short-container-title:Journal of Biomedicine and Biotechnology

Author:

Mahyudin Nor Ainy¹²³,Blunt John W.⁴,Cole Anthony L. J.²,Munro Murray H. G.⁴

Affiliation:

1. Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, 43400 Serdang, Malaysia

2. School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand

3. Institute of Bioscience, Universiti Putra Malaysia, Selangor, 43400 Serdang, Malaysia

4. Department of Chemistry, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand

Abstract

The application of an HPLC bioactivity profiling/microtiter plate technique in conjunction with microprobe NMR instrumentation and access to the AntiMarin database has led to the isolation of a new1. In this example,1was isolated from a cytotoxic fraction of an extract obtained from marine-derivedStreptomycessp. cultured on Starch Casein Agar (SCA) medium. The 1D and 2D1H NMR and ESIMS data obtained from 20 μg of compound1fully defined the structure. The known2was also isolated and readily dereplicated using this approach.

Funder

Public Service Department of Malaysia

Publisher

Hindawi Limited

Subject

Health, Toxicology and Mutagenesis,Genetics,Molecular Biology,Molecular Medicine,General Medicine,Biotechnology

Link

http://downloads.hindawi.com/journals/bmri/2012/894708.pdf

Reference13 articles.

1. Evolving Trends in the Dereplication of Natural Product Extracts: New Methodology for Rapid, Small-Scale Investigation of Natural Product Extracts

2. Evolving Trends in the Dereplication of Natural Product Extracts. 2. The Isolation of Chrysaibol, an Antibiotic Peptaibol from a New Zealand Sample of the Mycoparasitic Fungus Sepedonium chrysospermum

3. Resorpthiomycin, a novel antitumor antibiotic. II. Physico-chemical properties and structure elucidation.