Author:
Hai Yang,Wei Mei-Yan,Wang Chang-Yun,Gu Yu-Cheng,Shao Chang-Lun
Abstract
AbstractNatural products derived from marine microorganisms have received great attention as a potential resource of new compound entities for drug discovery. The unique marine environment brings us a large group of sulfur-containing natural products with abundant biological functionality including antitumor, antibiotic, anti-inflammatory and antiviral activities. We reviewed all the 484 sulfur-containing natural products (non-sulfated) isolated from marine microorganisms, of which 59.9% are thioethers, 29.8% are thiazole/thiazoline-containing compounds and 10.3% are sulfoxides, sulfones, thioesters and many others. A selection of 133 compounds was further discussed on their structure–activity relationships, mechanisms of action, biosynthesis, and druggability. This is the first systematic review on sulfur-containing natural products from marine microorganisms conducted from January 1987, when the first one was reported, to December 2020.
Publisher
Springer Science and Business Media LLC
Subject
Aquatic Science,Ecology, Evolution, Behavior and Systematics,Oceanography,Biotechnology
Cited by
73 articles.
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