Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds-Reference-Cited by-同舟云学术

Activation of Leukopoiesis in Rat Blood with Trimecaine-Based Ionic Compounds

Published:2020-01-13 Issue: Volume:2020 Page:1-7
ISSN:2314-6133
Container-title:BioMed Research International
language:en
Short-container-title:BioMed Research International

Author:

Baktybayeva Lyailya¹,Yu Valentina²³^ORCID,Zazybin Alexey³⁴^ORCID,Zolotareva Darya⁴,Dauletbakov Anuar³⁴

Affiliation:

1. Biology and Biotechnology Department, Al-Farabi Kazakh National University, 050040 Almaty, Kazakhstan

2. A. B. Bekturov Institute of Chemical Sciences, 050000 Almaty, Kazakhstan

3. Center of Chemical Engineering, Kazakh-British Technical University, 050000 Almaty, Kazakhstan

4. School of Chemical & Biochemical Engineering, Satbayev University, 050013 Almaty, Kazakhstan

Abstract

A study of myelostimulating activity of ionic compounds-trimecaine alkyl iodide derivatives under the cipher BIV (BIV-117, BIV-118, and BIV-119) was conducted on a model of doxorubicin pancytopenia in white laboratory rats. It was established that the compounds BIV-117 and BIV-119 had a pronounced leukopoiesis-stimulating activity, exceeding the activity of the methyluracil as a comparison drug. Compounds BIV-117 and BIV-119 had erythropoiesis- and thrombocytopoiesis-stimulating activity at the level of methyluracil.

Funder

Ministry of Education and Science of the Republic of Kazakhstan

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://downloads.hindawi.com/journals/bmri/2020/7636290.pdf

Reference7 articles.

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2. Immunostimulating Agents: What Next?. A Review of Their Present and Potential Medical Applications

3. N-ethoxyethylpiperidine, Trimecaine and Piromecaine Based Ionic Compounds: Synthesis and Prediction of Biological Activity

4. Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators

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