Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators

Published:2018 Issue: Volume:2018 Page:1-9
ISSN:2090-9063
Container-title:Journal of Chemistry
language:en
Short-container-title:Journal of Chemistry

Author:

Yu Valentina¹^ORCID,Ten Assel¹,Baktybayeva Lyailya²,Sagatbekova Indira¹,Praliyev Kaldybay¹,Zolotareva Darya³,Seilkhanov Tulegen⁴,Zazybin Alexey³⁵^ORCID

Affiliation:

1. Institute of Chemical Sciences Named after A. B. Bekturov, Walikhanov Str., No. 106, Almaty 050010, Kazakhstan

2. Al-Farabi Kazakh National University, Al Farabi Av., No. 71, Almaty 050004, Kazakhstan

3. School of Chemical Engineering, Kazakh-British Technical University, 59 Tole-bi Str., Almaty 050000, Kazakhstan

4. Laboratory of Engineering Profile NMR Spectroscopy, Sh. Ualikhanov Kokshetau State University, Abay Str., No. 76, Kokshetau 020000, Kazakhstan

5. School of Chemical & Biochemical Engineering, Satbayev University, 22a Satpayev Str., Almaty 050013, Kazakhstan

Abstract

Spiroconnected N-alkoxyalkylpiperidine hydantoins were obtained via the Strecker reaction of cyanohydrin with ammonium carbonate. 1,3,8-Triazaspiro[4.5]decane-2,4-diones have shown the myelostimulating activity in the artificially induced (with cyclophosphamide) myelodepressive syndrome. The compounds significantly accelerated the regeneration of lymphocyte and granulocyte cell pool of bone marrow hematopoiesis.

Funder

Ministry of Education and Science of the Republic of Kazakhstan

Publisher

Hindawi Limited

Subject

General Chemistry

Link

http://downloads.hindawi.com/journals/jchem/2018/7346835.pdf

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