Regulatory T Cells and Parasites

Author:

Velavan TP.1,Ojurongbe Olusola12

Affiliation:

1. Institute for Tropical Medicine, University of Tübingen, 72074 Tübingen, Germany

2. Department of Medical Microbiology and Parasitology, Ladoke Akintola University, PMB 4400, Osogbo, Nigeria

Abstract

Human host encounters a wide array of parasites; however, the crucial aspect is the failure of the host immune system to clear these parasites despite antigen recognition. In the recent past, a new immunological concept has emerged, which provides a framework to better understand several aspects of host susceptibility to parasitic infection. It is widely believed that parasites are able to modulate the magnitude of effector responses by inducing regulatory T cell (Tregs) population and several studies have investigated whether this cell population plays a role in balancing protective immunity and pathogenesis during parasite infection. This review discusses the several mechanism of Treg-mediated immunosuppression in the human host and focuses on the functional role of Tregs and regulatory gene polymorphisms in infectious diseases.

Publisher

Hindawi Limited

Subject

Health, Toxicology and Mutagenesis,Genetics,Molecular Biology,Molecular Medicine,General Medicine,Biotechnology

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