Affiliation:
1. Department of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USA
2. Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
Abstract
Objective. To summarize the recent studies on effect of conjugated linoleic acid (CLA) on hepatic steatosis and hepatic and adipose lipid metabolism highlighting the potential regulatory mechanisms.Methods. Sixty-four published experiments were summarized in whichtrans-10,cis-12 CLA was fed either alone or in combination with other CLA isomers to mice, rats, hamsters, and humans were compared.Summary and Conclusions. Dietarytrans-10,cis-12 CLA induces a severe hepatic steatosis in mice with a more muted response in other species. Regardless of species, when hepatic steatosis was present, a concurrent decrease in body adiposity was observed, suggesting that hepatic lipid accumulation is a result of uptake of mobilized fatty acids (FA) from adipose tissue and the liver's inability to sufficiently increase FA oxidation and export of synthesized triglycerides. The potential role of liver FA composition, insulin secretion and sensitivity, adipokine, and inflammatory responses are discussed as potential mechanisms behind CLA-induced hepatic steatosis.
Subject
Nutrition and Dietetics,Food Science,Endocrinology, Diabetes and Metabolism
Cited by
69 articles.
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