The Relationship between Polymorphisms in the Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women-Reference-Cited by-同舟云学术

The Relationship between Polymorphisms in the Vitamin D Receptor Gene and Bone Mineral Density in Postmenopausal Women

Published:2014-01-09 Issue: Volume:2014 Page:1-7
ISSN:2090-8687
Container-title:ISRN Genetics
language:en
Short-container-title:ISRN Genetics

Author:

Moran Jose M.¹,Rodriguez-Velasco Francisco J.¹,Roncero-Martin Raul¹^ORCID,Rey-Sanchez Purificación¹,Martinez Mariana¹,Pedrera-Zamorano Juan D.¹²

Affiliation:

1. Metabolic Bone Diseases Research Group, University of Extremadura, 10071 Cáceres, Spain

2. Departamento de Enfermería, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Avenida Universidad s/n, 10071 Cáceres, Spain

Abstract

The objective of this study was to identify, through a systematic review of the literature, Vitamin D receptor gene (VDR) polymorphisms related to osteoporosis and their effects on bone mineral density (BMD). The articles dated between January 2000 and December 2011 in the Scielo and PubMed databases were reviewed. A total of 23 articles that studied the association between the BsmI, ApaI, FokI, and TaqI polymorphisms and bone mineral density in postmenopausal women were selected. We found systematic studies/meta-analysis (level E-I) and case-control/cohort (level E-IV) studies. No definite conclusions can be made regarding the association of BsmI, ApaI, FokI, and TaqI polymorphisms with BMD among postmenopausal women. Larger and more rigorous analytical studies with consideration of gene-gene/environment interactions are needed to further dissect the mechanisms by which VDR alleles influence BMD.

Publisher

Hindawi Limited

Subject

General Earth and Planetary Sciences,General Environmental Science

Link

http://downloads.hindawi.com/archive/2014/549457.pdf

Reference45 articles.

1. Consensus development conference: Diagnosis, prophylaxis, and treatment of osteoporosis

2. Genetics of osteoporosis: accelerating pace in gene identification and validation

3. Genetic determinants of bone mass in adults. A twin study.

4. Reduced Bone Mass in Daughters of Women with Osteoporosis

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bone mineral density in high-level endurance runners: Part B—genotype-dependent characteristics;European Journal of Applied Physiology;2021-09-22

2. Vitamin D Receptor FokI, ApaI, and TaqI Polymorphisms in Lead Exposed Subjects From Saudi Arabia;Frontiers in Genetics;2019-04-26

3. Association of Vitamin D Receptor BsmI Gene Polymorphism with BMD Z-Score in Iranian Children and Adolescents (9 - 18 Years Old);International Journal of Endocrinology and Metabolism;2019-04-23