von Willebrand Factor and Oxidative Stress Parameters in Acute Coronary Syndromes

Author:

Koprivica Zoran1ORCID,Djordjevic Dusica2ORCID,Vuletic Milena2ORCID,Zivkovic Vladimir2ORCID,Barudzic Nevena2ORCID,Andjelkovic Nebojsa2,Djuric Dragan3,Iric-Cupic Violeta4ORCID,Krkeljic Jelena2,Jakovljevic Vladimir2ORCID

Affiliation:

1. Health Centre, 32 300 Gornji Milanovac, Serbia

2. Department of Physiology, Faculty of Medicine, University of Kragujevac, 34 000 Kragujevac, Serbia

3. Institute of Physiology “Richard Burian”, School of Medicine, University of Belgrade, 11 000 Belgrade, Serbia

4. University Hospital Centre “Kragujevac” and Faculty of Medicine, University of Kragujevac, 34 000 Kragujevac, Serbia

Abstract

Considering the role of von Willebrand factor (vWf) in hemostasis, and the role of oxidative stress in the development of endothelial dysfunction and atherosclerotic disease, the aim of our study was to investigate the relationship between vWf, parameters of oxidative stress and different types of acute coronary syndromes (ACS). Levels of vWf activity (vWfAct), vWf antigen (vWfAg), nitric oxide (estimated through nitrites–NO2), superoxide anion radical (O2), hydrogen peroxide (H2O2), index of lipid peroxidation (estimated through thiobarbituric acid reactive substances–TBARS), superoxide dismutase (SOD) and catalase (CAT) activity of 115 patients were compared with those of 40 healthy controls. ACS patients had significantly higher vWfAct and vWfAg levels, as well as TBARS levels, while their levels of NO2, H2O2, SOD and CAT activities were lower than controls'. vWfAg showed high specificity and sensitivity as a test to reveal healthy or diseased subjects. Multivariant logistic regression marked only vWfAg and TBARS as parameters that were under independent effect of ACS type. The results of our study support the implementation of vWf in clinical rutine and into therapeutic targets, and suggest that ACS patients are in need of antioxidant supplementation to improve their impaired antioxidant defence.

Publisher

Hindawi Limited

Subject

Cell Biology,Ageing,General Medicine,Biochemistry

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